The novel dual functions of this dendrite receptor provide an intriguing example of how membrane proteins can use different mechanisms to locally fine-tune actin dynamics. Second, the HPO-30 ICD directly binds to actin filaments, which stabilizes actin structures by preventing both actin polymerization and depolymerization. For proper neuronal function to occur, the neuron must have the correct number of input centers, or dendrites, which look like branches on a tree. Given that 97 of a motoneurons receptive area is provided by dendrites, dendritic branching and overall extension are physiologically important in. First, the unstructured HPO-30 ICD undergoes dimerization and folding into a three-dimensional structure in order to bind the WRC. Here we report biochemical and structural characterization of this interaction, revealing that the intracellular domain (ICD) of HPO-30 uses two novel mechanisms to regulate the actin cytoskeleton. leading to a tolerogenic dendritic cell phenotype. In this complex, the transmembrane protein HPO-30 recruits the WAVE Regulatory Complex (WRC) to dendrite branching sites, where WRC stimulates the Arp2/3 complex to polymerize actin. If, however, the tree that you own, or a branch from it, fell as a result of. They are formed from the branching ends of axons of receptor cells and from the outer (dendritic) branches of interneurons, known in vertebrates as mitral. elegans PVD sensory neuron identified a multi-protein signaling complex that bridges extracellular cues with intracellular actin remodeling to promote high-order dendrite branching. Dendrite morphogenesis is essential to neural circuit formation, but the molecular mechanisms that control the growth of complicated dendrite branches are not well understood.

Dendrite branching